*In order to receive Semaglutide shipment via Mail. All patients must consent to treatment. Please consent to treatment by signing the Consent To Treat Form.

Consent To Treat (jotform.com)

Semaglutide is a member of a class of drugs that have been used for diabetes management for over a decade - GLPI-RAs (glucagon-like peptide I receptor agonists). The weight loss effects of these agents have been known for some time, however, Semaglutide appears to be the "best-in-class" GLP-1 RA for weight loss and was recently approved for weight loss by the FDA under the brand name Wegovy®.

How well does Semaglutide work?

Low-dose Semaglutide (1.0mg) once weekly resulted in an average 11-pound weight loss in 12 weeks.

A recent 20-week, phase II trial investigated the effects of subcutaneous administration of Semaglutide 2.4 mg on gastric emptying, appetite, and energy intake in patients. Patients receiving Semaglutide 2.4 mg in this trial lost 9.9% of their body weight, compared with 0.4% in those receiving a placebo.

High-dose (2.4mg) Semaglutide has been studied in nondiabetic patients suffering from obesity. The New England Journal of Medicine's publication of the STEP trial revealed more than 50 percent of trial participants lost 15 percent of their body weight, and between 33 to 40 percent are losing 20 percent of their body weight. This number is superior to the current best weight loss agent (phentermine plus topiramate; approximately 10% body weight loss in a year).

How does Semaglutide work?

Semaglutide mimics the effect of "feeling full" resulting in a decreased caloric intake. Semaglutide will delay gastric emptying by reducing glucagon secretion in a glucose-dependent manner. The delay in gastric emptying can reduce appetite, improve control of eating, and reduce food cravings.

Does Semaglutide have side effects?

The most common side effects are nausea, diarrhea, vomiting, constipation, stomach (abdomen) pain, headache, tiredness (fatigue), upset stomach, dizziness, feeling bloated, belching, gas, stomach flu, and heartburn. Note that most of these are manageable by proper dosing and some overlap with the intended effect of "feeling full".

Are you a candidate for Semaglutide?

There are only two qualifications for Semaglutide:

• A BMI over 30 and no weight-related complications

• A BMI over 27 with weight-related complications

Contraindications:

There are rare situations where Semaglutide is contraindicated.

Patients with a personal or family history of medullary thyroid carcinoma or patients with

Multiple Endocrine Neoplasia syndrome types 2 (MEN 2)

Why is the weight loss goal 10%? What if I want to lose more weight?

The weight loss goal is based on clinical research showing that 10% is the amount of weight you can lose and keep off with the combination of an FDA-approved metabolic medication and accountability coaching. Many patients will lose more than 10%, but 10% is the goal because it leads to clinically-significant improvements across all metabolic and inflammatory markers.

10% body weight loss has been shown to lower several risk factors for cardiovascular disease including high blood pressure, high cholesterol, and diabetes. A body weight loss of 10% has also been proven to reduce symptoms of depression, arthritis, and sleep apnea while improving the overall quality of life. Further, studies have found that losing 10% of your body weight is generally a realistic and attainable goal for most people given biological, genetic, and environmental factors.

What will my food goals be?

Establishing a sustainable and flexible approach to nutrition

Minimizing fast-digesting carbs

Making healthier choices that include protein, fiber, and healthy fats- without restricting or counting calories

Is the medication safe?

GLP-1s are FDA-approved and safe. They have been widely used since 2005 and are generally very well tolerated, with minimal side effects.

Can I take additional weight loss medication, in addition to GLP-1s?

We do not recommend taking any weight loss medication that is not a GLP-1 during your weight loss program.